The Venereal Origin of Granuloma Inguinale *A paper read at the Indian Science Congress at Calcutta in January 1935.
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چکیده
ulcer which often heals but breaks down again. One of us (Bhaskara Menon, 1933) has drawn attention to this feature in the history of cases studied in the General Hospital and the Government Rayapuram Hospital, Madras. In a series of patients, the primary lesion was followed by cicatrization and deformity of the prepuce and the patients came into hospital for circumcision. The subsequent history of these cases showed that the circumcision wound did not heal, but continued to break down till all the clinical features of granuloma were reproduced. In other instances, the sore had healed, but had broken down again and the granuloma had developed. The site of the lesion itself is, in most cases, the genitalia, and ulceration of the groin is secondary to spread of infection from the genitalia. It has been argued by Nair and Pandalai (1934) that lack of a primary involvement of the cervix and the vagina is against a venereal origin. But the fact that the organism attacks moist stratified surface epithelium of muco-cutaneous junctions and lives inside epithelial cells is enough to explain this feature. The soft epithelial cells of mucous membranes probably do not afford
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